Protein tyrosine phosphatase non-receptor type 2 and inflammatory bowel disease

UCSD MOLECULE PAGES Tyrosine-protein phosphatase non-receptor type 2

TC-PTP is a ubiquitous non-receptor type protein tyrosine phosphatase that shows highest expression in hematopoietic tissues. It regulates many signal transduction pathways in hematopoietic as well as non-hematopoietic cells. TCPTP has two splice variants, an endoplasmic reticulum-localized TC48, and predominantly nuclear TC45. Upon various stress conditions and insulin stimuli, TC45 comes out ...

PTPN 1 ( protein tyrosine phosphatase , non - receptor type 1 )

PTPRA ( protein tyrosine phosphatase , receptor type , A )

Review on PTPRA, with data on DNA/RNA expression, on the protein encoded, and the functional importance of the gene.

A RP-UFLC Assay for Protein Tyrosine Phosphatases: Focus on Protein Tyrosine Phosphatase Non-Receptor Type 2 (PTPN2)

Protein tyrosine phosphatases (PTPs) are involved in numerous signaling pathways and dysfunctions of certain of these enzymes have been linked to several human diseases including cancer and autoimmune diseases. PTPN2 is a PTP mainly expressed in hematopoietic cells and involved in growth factor and JAK/STAT signaling pathways. Loss of function analyses in patients with mutation/deletion of the ...

Type 2 Diabetes Mellitus and Protein-Tyrosine Phosphatase 1B1

Diabetes is a common metabolic disease which characterized by hyperglycemia, mainly divided into type 1 diabetes mellitus and type 2 diabetes mellitus. Insulin-dependent type 1 diabetes mostly resulted from the damage of pancreatic β cells which makes the absolute lack of insulin; Type 2 diabetes, which insulin independent, the mainly initial factors are insulin resistance (IR) and the relative...